Expression of osteopontin in colorectal cancer with clinical pathological characteristics and prognosis
- VernacularTitle:骨桥蛋白表达与结直肠癌临床病理特征及预后的关系
- Author:
Pengfei YIN
;
Jiacong CHANG
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
osteopontin;
immunohistochemistry;
prognostic
- From:
Acta Universitatis Medicinalis Anhui
2015;50(10):1493-1496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the osteopontin ( OPN ) expression of colorectal cancer tissues with the clinical characteristics and prognosis. Methods The expressions of OPN in colorectal cancer tissues and their corresponding para-cancerous tissues from 112 cases of colorectal cancer patients were detccted by immunohistochemistry . The relationship between the expressions of OPN and the clinicopathological features in pait-ients with colorectal cancer were analyzed. Results The OPN expression of colorectal cancer tissues was signifi-cantly higher than their corresponding adjacent normal tissues, the difference was statistically significant ( P <0. 05). Its expression was significantly associated with tumor size, histological differentiation, TNM stage, tumor status. Disease-free survival, and overall survival time of OPN protein positive expression group were lower than that of the negative group, respectively, the differences were statistically significant(P<0. 05). The expression of OPN in colorectal cancer tissues was an independent prognostic factor. Conclusion The expression of OPN is sig-nificantly increased in colorectal cancer tissues, and the positive expression of OPN is associated with the prognostic of patients with colorectal cancer.
