Effects ofLinggan Wuwei Jiangxin Decoction on cAMP, cAMP Dependent PKA, and AQP5 of Asthma Rats
10.3969/j.issn.1005-5304.2015.10.019
- VernacularTitle:苓甘五味姜辛汤对哮喘大鼠环腺苷酸、环腺苷酸依赖性蛋白激酶A及水通道蛋白5的影响
- Author:
Yan LI
;
Rongke LI
;
Yan WANG
;
Yunyan DUAN
;
Xiangdong ZHU
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
Linggan Wuwei Jiangxin Decoction;
cAMP;
PKA;
AQP5;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(10):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects ofLinggan Wuwei Jiangxin Decoction on contents of cAMP, cAMP dependent PKA and AQP5 of model rats with clod phlegm-fluid lying latent in the lung asthma;To discuss its mechanism.Methods Ovalbumin intraperitoneal injection and atomization motivation + cold stimulation were used to establish models. Ninety rats were randomly divided into blank control group, model group, hexadecadrol group, andLinggan Wuwei Jiangxin Decoction low-, medium-, high-dose groups. All administration groups were treated with relevant medicine. The levels of cAMP, PKA, and AQP5 were detected by ELISA.Results Compared with the blank control group, the levels of cAMP, PKA, and AQP5 of rats in model group decreased obviously (P<0.05). Compared with the model group, the levels of cAMP, PKA, and AQP5 of rats in all administration groups increased (P<0.05), which increased dramatically inLinggan Wuwei Jiangxin Decoction high-dose group.ConclusionLinggan Wuwei Jiangxin Decoction can regulate the normal secretion of cAMP, PKA, and AQP5 in serum of rats with clod phlegm-fluid lying latent in the lung asthma, increase secretion of air passage liquid and decrease mucoprotein concentration, through which plays the role of treating asthma.
