Expression and significance of STIP1 and ER-αin papillary thyroid carcinomas
10.13315/j.cnki.cjcep.2015.09.013
- VernacularTitle:甲状腺乳头状癌中STIP1、ER-α的表达及其意义
- Author:
Yue YANG
;
Zhiyong ZHANG
;
Hui FANG
;
Yaojie HU
;
Chenpeng WU
;
Yueming HU
;
Guyue ZHANG
;
Ying YANG
- Publication Type:Journal Article
- Keywords:
papillary neoplasm;
thyroid carcinoma;
STIP1;
ER-α;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(9):1017-1020
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To detect the expressions of stress induced phosphoprotein 1 (STIP1) and estrogen receptor-α(ER-α) in papil-lary thyroid carcinoma and to analyse the relationship between STIP1 and ER-α. Methods 54 cases of paraffin-embedded tissues of papillary thyroid carcinoma, 18 cases of papillary thyroid carcinoma with lymph node metastasis, 15 cases of Hashimoto’ s thyroiditis, 10 cases of adjacent normal thyroid tissue were collected. The expressions of STIP1 and ER-αwere detected by immunohistochemistry, and the relationship between the expressions and clinicopathological features of papillary thyroid carcinoma was analyzed. Results The expression of STIP1 and ER-α in papillary thyroid cancer group ( 55. 6% and 44. 4%) were higher than that of normal thyroid group (10% and 0) and Hashimoto’s thyroiditis group (8. 3% and 0, all P<0. 05). STIP1 expressions was related to lymph node metastasis ( P<0. 05 ) , while ER-α expression was related to gender, TG-Ab and the merger of nodular goiter, but not related to lymph node metastasis (P>0. 05). The expressions of STIP1 and ER-α in papillary thyroid carcinoma were not related to patients’ age , tumor location, number of tumors, tumer size, invasion of capsule, the concomitant Hashimoto’ s thyroiditis and TPO-Ab ( all P>0. 05). And the expressions of STIP1 was not related to gender, TG-Ab and the merger of nodular goiter (all P>0. 05). A positive correlation was found between the expressions of STIP1 and ER-αin thyroid papillary carcinoma (P<0. 05). Conclusion STIP1 and ER-α in papillary thyroid carcinoma may be related with lymph node metastasis.
