Clinical pathological analysis of 11 cases of pancreatic solid-pseudopapillary tumors
10.13315/j.cnki.cjcep.2015.09.015
- VernacularTitle:胰腺实性-假乳头状肿瘤11例临床病理分析
- Author:
Xi HUANG
;
Linming LU
;
Xiangming WANG
;
Jingjing MEI
- Publication Type:Journal Article
- Keywords:
solid-pseudopapillary tumor;
β-catenin signaling pathway;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(9):1026-1030
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathlogic characteristic, diagnosis and histogenesis of pancreatic solid-pseudopapillary tumors ( SPPT) . Methods Combined with relevant literature, the clinical history, histopathological features and immunohistochemi-cal characteristics were analyzed in 11 cases of SPPT. Results There were 10 female patients and only 1 male in total 11 cases, aged from1 7 to 60 years (mean 33). The sizes of tumors were from 3. 2 to 10. 0 cm. Histologically, they were composed of papillary and microcysticsolid structures. Pseudopapillary with a fibrovascular core was remarkable. Immunohistochemically, the tumors expressed EMA (1/11), vimentin (10/11), NSE (11/11), Syn (7/11), CgA (1/11), CD56 (11/11), CD10 (11/11), PR (9/11), CD99 (9/11),α-AT (11/11),β-catenin (11/11), E-cadherin (11/11), Cyclin D1 (11/11), c-Myc (11/11). 6 patients were followed up for a period of 20 to 112 months, and they were all alive and had no recurrence and metastasis. Conclusions SPPT is a tumor with low malignancy of the pancreas that most frequently affect young females. SPPT may be derived from multipotent stem cells and closely related withβ-catenin signaling pathway. Pathological morphology and immunohistochemistry are very important to the diag-nosis and differential diagnosis of SPPT.
