Inhibitory Effects ofQi-Zhu Granules on Early Proteinuria in Diabetic Nephropathy Rats with Syndrome ofQi-yin Deficiency and Phlegm Blocking Collaterals
10.11842/wst.2015.07.011
- VernacularTitle:芪术颗粒对糖尿病肾病气阴两虚、痰浊阻络证大鼠早期蛋白尿抑制作用
- Author:
Xiaohua HONG
;
Jianxun REN
;
Yanghui WANG
;
Long JIN
;
Bin YANG
;
Xiaoxia DONG
;
Wei ZHANG
;
Zhengyan GE
;
Hongkun LI
;
Jianxun LIU
- Publication Type:Journal Article
- Keywords:
Qi-Zhu granules;
diabetic nephropathy;
early proteinuria;
syndrome
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(7):1392-1397
- CountryChina
- Language:Chinese
-
Abstract:
ThisstudywasaimedtoobservetheinhibitoryeffectsofQi-Zhu (QZ)granulesonearlyproteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. A total of 44 rats were randomly divided into the blank group, model group, Huang-Kui capsule group, QZ granules group. The rat model of diabetic nephropathy with syndrome of qi-yin deficiency and phlegm blocking collaterals was induced by the combination of unilateral renal artery ligation, diet of high-calorie and high cholesterol, and intraperitoneal injection of low-dose streptozotocin. The medication was given for 8 weeks. The concentrations of protein and creatinine in urine were observed on the 4th week. The blood glucose, blood lipids, liver function and renal pathological changes were observed at the end of the experiment. The results showed that compared with the model group, QZ granules can obvious suppress early proteinuria in diabetic nephropathy, promote creatinine excretion, regulate blood lipid metabolism, protect liver function and improve renal pathological changes. It was concluded that QZ granules had independent inhibition effect on early proteinuria in diabetic nephropathy rats with syndrome of qi-yin deficiency and phlegm blocking collaterals. The effect was independent of lowing blood glucose. It represented the corresponding relation between the syndrome and efficacy in Chinese herb compounds.
