Comparison of clinical-pathological features and Ki-67 expression profile between triple-negative breast cancer (TNBC) and non-triple-negative cancer
10.11958/j.issn.0253-9896.2015.08.018
- VernacularTitle:三阴与非三阴乳腺癌的临床病理特征及Ki-67表达的对比研究
- Author:
Ying ZHANG
;
Zhanping REN
;
Yuan ZHANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
receptors,estrogen;
receptor,epidermal growth factor;
progesterone,receptor;
Ki67
- From:
Tianjin Medical Journal
2015;(8):896-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare clinical-pathological features and Ki-67 expression profile between TNBC and Non-triple-negative cancer (NTNBC). Methods The expressions of ER, PR and HER2 were examined by immunohisto?chemical Envision double staining in 226 cases of breast cancer. All cases were divided into triple-negative and non-triple-negative group according to expressions of these three episodes. And Ki-67 expressions in two groups were assessed by im?munohistochemical method. The difference of Ki-67 positive index between these two groups and the difference of Ki-67 positive index between different clinical-pathological features were both analyzed by comparative analysis. Results In pa?tients with TNBC, tumor size, lymph node metastasis rate and Ki-67 index were all significantly higher than that in NTNBC. No significant difference in age and histological grade were detected between these two groups. The expression of Ki-67 was not significant correlated with age, tumor size,lymph node status and histological grade in these two groups. Conclusion Patients with triple-negative breast cancer were with larger tumor size, higher proliferation, more lymph node metastasis and poorer prognosis.
