Clinical analysis of 9 cases of type 2 diabetes mellitus complicated with invasive pulmonary aspergillosis
- VernacularTitle:2型糖尿病合并侵袭性肺曲霉病9例临床分析
- Author:
Xiudi HAN
;
Xuedong LIU
;
Yunjie GE
;
Weiye ZHAO
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
invasive pulmonary aspergillosis;
diagnosis;
treatment
- From:
Chinese Journal of Infection and Chemotherapy
2015;(5):424-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and prognosis in the patients with type 2 diabetes mellitus and invasive pulmonary aspergillosis(IPA) for better management of the disease .Methods Clinical data of 9 cases of type 2 diabetes associated with IPA treated in Qingdao Municipal Hospital from January 2008 to December 2013 were analyzed retrospectively . Results The diagnosis of IPA was proven in 5 and probable in 4 of the 9 patients .The main clinical manifestations were fever , cough and expectoration .The findings of CT scan mainly showed pulmonary nodules along the bronchovascular bundle and cavity signs .Bronchoscopy showed congestion ,edema ,and erosion of bronchial mucosa covered with yellow‐white or brown pus ,partially or completely blocking the lumen .Antifungal treatment was effective for 4 patients .The other five patients died . Conclusions Type 2 diabetes mellitus is a risk factor for developing invasive pulmonary aspergillosis .Early diagnosis and proper treatment are critical for improved prognosis .
