The value of perfusion CT in assessing the response of local advanced cervical squamous cancer to neoadjuvant chemotherapy
10.3969/j.issn.1002-1671.2015.09.019
- VernacularTitle:CT 灌注在局部晚期宫颈鳞癌新辅助化疗疗效评价中的价值
- Author:
Wenguang HAN
;
Yong ZHOU
;
Hongmei WANG
;
Yingying YU
;
Zhi WEN
- Publication Type:Journal Article
- Keywords:
computed tomography;
perfusion imaging;
cervical cancer;
neoadjuvant chemotherapy
- From:
Journal of Practical Radiology
2015;(9):1479-1482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of perfusion CT in the evaluation of neoadjuvant chemotherapy in locally advanced squamous cell carcinoma.Methods Sixty-seven patients with Ib2-IIb squamous cell carcinoma of the cervix underwent CT perfusion imaging before neoadjuvant chemotherapy to measure blood flow (BF),blood volume (BV),peak time (MTT),permeability sur-face (PMB),perfusion time to peak (TTP)and MIP(HU);and underwent routine enhancement CT after the two course of neoadju-vant chemotherapy treatment to measure tumor size,and evaluate the therapeutic effect.Results Among 67 patients,48 patents were effective (2 completely remission and 46 partial remission),and 1 9 patients were ineffective (1 5 stable and 4 progressed),with the overall response rate of 71.6%.The differences of PMB and BV value between effective and ineffective group were statistically significant before neoadjuvant chemotherapy (P <0.001).The BF,MTT,TTP value were no significant difference between effec-tive and ineffective group before neoadjuvant chemotherapy (P >0.05).The BV and PMB value were relatively higher in the patients with effective chemotherapy.Conclusion CT perfusion imaging could measure the BV and PMB value of the tumor before neoadju-vant chemotherapy to provide the basis for treatment selection.
