Acute Toxicity Study on Intragastric Administration of Different ProcessedRadix Aconiti Lateralis PraeparataProducts to Beagle Dogs
10.11842/wst.2015.07.018
- VernacularTitle:附子不同炮制品灌胃Beagle犬的急性毒性研究
- Author:
Yuqin SONG
;
Xue ZHANG
;
Yanhong DONG
;
Liangping DAI
;
Cheng PENG
;
Xiaofang XIE
- Publication Type:Journal Article
- Keywords:
Radix Aconiti Lateralis Praeparata;
processed products;
acute toxicity;
experimental research
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(7):1432-1437
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the acute toxicities on intragastric administration of differentRadix Aconiti Lateralis Praeparataprocessed products to Beagle dogs. A total of 16 healthy and qualified Beagle dogs were randomly divided into the blank group,Pao-Fu-Pian(PFP) group,Pao-Tian-Xiong(PTX) group andHei-Shun-Pian(HSP) group according to the body weight. The intragastric administration of 4 g crude herb per kg was given. Before medication, 1 h, 24 h, and 3, 7, 14 days after medication, the body weight, food consumption, rectal temperature, electrocardiogram, blood routine and blood biochemistry were measured. The results showed that after medication, all dogs in three experimental groups were depressed. And there were significant differences in the electrolytes of blood. Among them, the HSP group was the most obvious one. The red blood cells, blood sugar and triglycerides of dogs in the PFP group had significant difference. The lymphocytes and blood sugar had significant difference of dogs in the PTX group. However, after the medication of HSP, the lymphocytes of the dogs were decreased significantly. It was concluded that the toxicity of three processed products followed the order of HSP > PFP > PTX.
