The expression and significance of IFN-γR and sIL-2R in plasma of patients with recurrent oral ulcer

VernacularTitle:IFN-γR 和 sIL-2R 在复发性口腔溃疡患者血浆中的表达及意义
Author: Xiaozhe MA ; Yanjun LI ; Aili FU ; Jiangnan XUE ; Ping YU
Publication Type:Journal Article
Keywords: Recurrent oral ulcer; T helper cells; IFN-γ; IFN-γR; IL-2; sIL-2R
From: Journal of Practical Stomatology 2015;(5):656-659
CountryChina
Language:Chinese
Abstract: Objective:To examine the plasma soluble interleukin 2 receptor (sIL-2R)and the expression of IFN-γR in helper T (Th)cells in peripheral blood of patients with recurrent oral ulcer(ROU).Methods:The peripheral blood was obtained from 21 pa-tients in active stage of ROU and 21 healthy controls.Flow cytometry was used to detect the quantity of IFN-γR in CD +4 T cells,ELISA was used to detect the level of sIL-2R.Results:The expression of IFN-γR in CD +4 T cells and sIL-2R content in plasma of the patients with ROU were significantly higher than those in the healthy controls(P <0.05).Conclusion:Over expression of IFN-γR in CD +4 T cells and sIL-2R in peripheral blood may be related to the genesis of ROU.