A Preliminary Research on the Efficacy and Toxicity of Yunaconitine and 8-deacetyl- yunaconitine Isolated from the Processed Products of Aconiti Knsnezoffii Radix
10.3969/j.issn.1005-5304.2015.10.017
- VernacularTitle:制黄草乌中滇乌碱及其转化产物8-去乙酰基滇乌头碱药效和毒性的初步研究
- Author:
Zhijun GUO
;
Xiaohua DUAN
;
Cuiling CHEN
;
Zhuya YANG
;
Wenhong TAN
;
Zhihong ZHOU
;
Xiaoxia MA
- Publication Type:Journal Article
- Keywords:
processed products of Aconiti Knsnezoffii Radix;
yunaconitine;
8-deacetyl- yunaconitine;
analgesic activity;
anti-inflammation activity;
acute toxicity;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(10):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct comparative study on the analgesic and anti-inflammatory effects as well as the acute toxicity of yunaconitine and 8-deacetyl-yunaconitine isolated from the processed products of Aconiti Knsnezoffii Radix.Methods The methods of hot plate test and writhing test were used to evaluate the analgesic effect. Anti-inflammation action was observed by the models of auricle swelling caused by dimethylbenzene. LD50 was determined by the method of Bliss.Results Yunaconitine and 8-deacetyl-yunaconitine have analgesia effect on the pain caused by hot-plate, but there were no statistically significant difference. The pain caused by acetic acid had obvious analgesic action. High and low dose of yunaconitine could significantly reduce the number of mice body torsion and extend the incubation period of pain in mice. The effect of 8-deacetyl-yunaconitine was remarkable only in the high dose. Compared with solvent group, there were little differences in inhibiting effect of auricle swelling caused by dimethylbenzene, and anti-inflammatory action was not exact. The poisonousness of yunaconitine was nearly 20 times of 8-deacetyl-yunaconitine.Conclusion Yunaconitine and 8-deacetyl-yunaconitine may be the analgesic medicine for peripheral analgesic effect. The poisonousness of 8-deacetyl-yunaconitine is less than yunaconitine, the effect is remarkable to the pain caused by acetic acid, and the security is high.
