Expression of OTUB1 in colon cancer and its clinical significance
10.13315/j.cnki.cjcep.2015.09.011
- VernacularTitle:结肠癌组织中OTUB1的表达及其临床意义
- Author:
Weina JIANG
;
Weiqing HUANG
;
Xin LIU
;
Hongyun LIU
;
Qingnuan KONG
;
Zenglei HAN
;
Hua CHEN
- Publication Type:Journal Article
- Keywords:
colon neoplasm;
OTUB1;
quantitative real-time PCR;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(9):1009-1012
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of OTUB1 in colon cancer and the relationship between its expression and some clinicopathologic parameters. Methods Quantitative real-time PCR and immunohistochemical SP method were carried out in selected colon cancer and normal mucosa tissues. Results OTUB1 mRNA in colon cancer was 3. 5-fold higher than the normal mucosa. The expression of OTUB1 protein in the colon cancer was significantly higher than normal mucosa (P<0. 05). Moreover, its expression in normal tissues, adenoma and colon cancer showed a gradually increasing trend (P<0. 05). The higher expression of OTUB1 in colon cancer was related with tumor size, differentiation and lymph node metastasis. Conclusions OTUB1 may play an important role in co-lon cancer development.
