Study on Qi-supplementing and Mind-tranquilizing Efficacy ofLing-Qi-JiaOral Solution on Heart-spleen Deficiency Mouse
10.11842/wst.2015.07.006
- VernacularTitle:灵芪加口服液对心脾两虚小鼠益气宁心安神功效研究
- Author:
Li XU
;
Wenting SONG
;
Bing HAN
;
Xiaodi FAN
;
Jie HAN
;
Guangrui WANG
;
Jianxun LIU
- Publication Type:Journal Article
- Keywords:
Ling-Qi-Jia oral solution;
heart-spleen deficiency;
qi-supplementing and mind-tranquilizing;
efficacy study
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(7):1361-1366
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the body weight and behavioral changes of heart-spleen deficiency mouseandtoassesstheefficacyofLing-Qi-Jia (LQJ)oralsolutiononqi-supplementingandmind-tranquilizing. The heart-spleen deficiency syndrome mouse model was established by using loading swimming anddrugdaily.Thebodyweight,foodconsumption,intestinepropulsion,tailsuspensiontest (TST),forced swimmingtest (FST),sleepingtimeandtheamountofbrainneurotransmitterweredetected.Theresultsshowed that mouse suffered loading swimming and drug formed heart-spleen deficiency syndrome model, which were indicated by lowering body weight and food consumption, shortened time in FST, prolonged accumulative immobility time in TST, intestine propulsion hyperfunction, shortened sleeping time and lowering brain neurotransmitter amount. LQJ oral solution can obviously improve experiment indexes mentioned above. It was concluded that LQJ oral solution, which can improve insomnia due to heart-spleen deficiency, might had close relation to the efficacy of qi-supplementing and mind-tranquilizing. Meanwhile, changes of brain neurotransmitters might also be the material basis on its efficacy.
