Research progress of genomic alterations and treatment of Ph-like acute lymphoblastic leukemia
10.3760/cma.j.issn.1009-9921.2015.09.018
- VernacularTitle:费城染色体样急性淋巴细胞白血病基因改变及治疗研究进展
- Author:
Shanshan GU
- Publication Type:Journal Article
- Keywords:
Ph-like acute lymphoblastic leukemia;
Genome;
Therapy;
Prognosis
- From:Journal of Leukemia & Lymphoma
2015;24(9):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Ph-like acute lymphoblastic leukemia (Ph-like ALL) involves various genomic alterations associated with high risk factors and poor clinical outcome, such as IKZF1, CRLF2, JAK1/2, EBF1-PDGFRB, ATF7IP, EPOR, SH2B3.JAK/STAT pathway and PI3K/mTOR pathway are likely to be the targets of Ph-like ALL.Here,the above genomic alterations and treatment progress are reviewed.
