Early diagnostic value of cerebrospinal fluids procalcitonin for the post-neurosurgery bacterial meningitis
10.3760/cma.j.issn.1008-6315.2015.11.011
- VernacularTitle:脑脊液降钙素原对开颅术后细菌性脑膜炎的早期诊断价值
- Author:
Guoxin ZHANG
;
Mingliang SUI
;
Jinsong ZHANG
- Publication Type:Journal Article
- Keywords:
Bacterial meningitis;
Procalcitonin;
Cerebrospinal fluid;
Craniotomy
- From:
Clinical Medicine of China
2015;31(11):995-999
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the early diagnostic value of cerebrospinal fluids (CSF) procalcitonin(PCT) for the post-neurosurgery bacterial meningitis (PNBM).Methods Conduct a prospective study in 34 patients who suspected PNBM in ICU of Kowloon Hospital of Suzhou.On the first day, all the patient blood samples were obtained for detection of routine blood count, C-reactive protein, PCT.Also, all the patient CSF samples were obtained for detection of routine CSF count, biochemical tests, PCT and for CSF culture.The patients were divided into PNBM group and non-PNBM group according to PNBM diagnostic criteria.Results Fifteen cases(44.12％) patients were diagnosed as PNBM,the other 19 cases were non infection group.Levels of CSF procalcitonin PCT 0.50 μg/L were significantly higher in patients with PNBM than those non-PNBM 0.29 μg/L on the first day(P＜0.01).The ROC curues indicated that the area under the curve (AUC) for CSF PCT was 0.846, it was significantly higher than the other traditional indicators' area.The cut off points of CSF procalcitonin was set to be 0.415 μg/L for patients with proven PNBM.The corresponding sensitivity, sepecificity were 80.0％ and 73.7％.Conclusion The level of the CSF procalcitonin may be valuable early diagnostic parameter for PNBM.Sensitivity and specificity of the CSF procalcitonin was higher than the other traditional indicators.
