Clinical observation of lafutidine treated in curing peptic ulcer
10.3760/cma.j.issn.1008-6315.2015.11.010
- VernacularTitle:拉呋替丁治疗消化性溃疡的效果及安全性观察
- Author:
Yanhua XIE
;
Xiaoru LIU
;
Yanhong XIE
- Publication Type:Journal Article
- Keywords:
Lafutidine;
Peptic ulcer;
Lansoprazole;
Gastroscope examination
- From:
Clinical Medicine of China
2015;31(11):992-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of application of lafutidine treated in curing peptic ulcer.Methods Eighty-four patients with peptic ulcer were randomly assigned to receive either lafutidine(10 mg) twice daily in 42 patients of cured group or lansoprazole (30 mg) once daily for 4 weeks in 42 patients of control group.Ulcer healing rate and clinical performance were examined after treatment.Results The first,third and seventh day of peptic ulcer healing rate were 38.09％ (16/42), 71.42％ (30/42) and 90.47％ (38/42) in the lansoprazole group and 23.81％ (10/42), 76.19％ (32/42) and 85.71％ (36/42) in the lafutidine group.There were no siginificant difference between two groups (P =0.157,0.620, 0.736).Gastroscope examination showed the complete healing rate, average healing rate and general clinical effectiveness were 61.90％(26/42) ,30.95％(13/42) and 97.61％(41/42) in the lansoprazole group,while the number for lafutidine group were 57.14％ (24/42), 28.57％ (12/42) and 95.23％ (40/42).There were no siginificant difference between two groups (P =0.657, 0.811, 1.000).No severe side-effect was occurred in both groups.Conclusion Use Lafutidine to cure peptic ulcer can promote healing effectively, improve patients' clinical symptoms which is similar to lansoprazole.
