Efficacy ofα1-blockers on expulsion urinary calculi post extracorporeal shock wave lithotripsy:a Meta-analysis
10.11958/j.issn.0253-9896.2015.08.025
- VernacularTitle:α1受体阻滞剂用于ESWL后排石有效性的Meta分析
- Author:
Quansong JI
;
Chundong ZHANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
urinary calculi;
adrenergic alpha-antagonists;
lithotripsy;
Meta-analysis
- From:
Tianjin Medical Journal
2015;(8):920-924
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the efficacy of α1-blocker in the treatment of urinary calculi post extracorporeal shock wave lithotripsy (ESWL). Methods Key words include Urinary calculi, Alpha-blocker, Randomized clinical trail, Ex?tracorporeal shockwave lithotripsy, et al were searched against databases include Pubmed, Embase, Cochrane Library data?bases and CNKI. All studies that reported effect ofα-blockers post ESWL were eligible for the analysis. Data was extracted through quality assessment and data filtering, then were analysed using RevMan 5.0. Results Fourteen randomized clinical trails with a total of 1 464 patients met the inclusion criteria. Pooled analysis showed a better stone clearance and shorter in?terval between stone fragment discharges (RR=1.21, 95%CI:1.10-1.33, P<0.05) and (SMD=-1.23, 95%CI:-2.09--0.36, P<0.05) respectively afterα1-blocker administration. However, evidence is still not convincible that it can reduced the fre?quency of colic episodes (RR=0.54,95%CI:0.28-1.02, P=0.06). Conclusion α1-blockers facilitates the expulsion of uri?nary calculi shown by a higher expulsion rate, a shorter expulsion interval during treatment. Adjunctive therapy with α1-blockers after ESWL is effective in the treatment of urinary calculi.
