Correlation of serum retinol binding protein 4 and cystatin C with pigmented pretibial pathes in type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2015.07.010
- VernacularTitle:视黄醇结合蛋白4、胱抑素 C 与2型糖尿病胫前色素沉着斑的相关性分析
- Author:
Congqing MIAO
;
Xinlong MENG
;
Dechuan LU
;
Peng DU
;
Yingzi CHEN
;
Aijuan FAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Pigmented pretibial pathes;
Retinol binding protein 4;
Cystatin C
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(7):601-603
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] A total of 165 type 2 diabetic patients were divided into two groups with pigmented pretibial pathes(PPP group) and no PPP( NPPP group). 50 subjects with normal glucose regulation were used as a control group(NGR group). The records of sex, age, diabetes duration, body mass index( BMI), systolic blood pressure (SBP), diastolic blood pressure, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, fasting blood glucose(FBG), 2 h postpradial plasma glucose(2hPG), triglyceride(TG), total cholesterol, HbA1C , retinol binding protein 4(RBP4), cystatin C(Cys C)were analyzed. The results showed that BMI,FBG, 2hPG, TG, and Cys C levels in NPPP group were higher than those in NGR group(all P<0. 01). The levels of BMI, SBP, FBG, 2hPG, TG, Cys C, and RBP4 in PPP group were higher than those in NGR group(P<0. 01 or P<0. 05), while diabetes duration, FBG, 2hPG, HbA1C , Cys C, and RBP4 in PPP group were higher than those in NPPP group ( P <0. 01). Pearson correlation analysis revealed that serum RBP4 and Cys C were in linear positive correlation(r=0. 77, P< 0. 01). The areas under receiver operating characteristic curve of RBP4 and Cys C were 0. 81 and 0. 78, respectively(P<0. 01). The results of binary logistic regression analysis showed that diabetes duration, HbA1C , RBP4 were related to PPP(r=0. 37, 0. 26, 0. 22, P<0. 05 or P<0. 01).
