Expression of BIM gene in papillary thyroid carcinoma and its association with the BRAFV600E mutation

VernacularTitle:甲状腺乳头状癌中 BIM 基因表达及其与 BRAFV600E 突变的相关性研究
Author: Denghui LIAO ; Ting WANG ; Zailiang YANG ; Lin GAN ; Zhen ZENG ; Yadong WANG ; Jie MIN ; Gang LUY
Publication Type:Journal Article
Keywords: Papillary thyroid carcinoma; BRAFV600E; BIM gene
From: Chinese Journal of Endocrinology and Metabolism 2015;(7):604-605
CountryChina
Language:Chinese
Abstract: To study the link between BRAFV600E status and the expression of BIM gene in papillary thyroid carcinoma( PTC) tissues and to analyze the association of these factors with clinicopathological characteristics. BRAFV600E status was determined by MASA-PCR, and qPCR was applied to detect the expression of BIM gene. Finally, the associations of these factors with clinicopathological characteristics were analysed. The rate of mutant BRAFV600E in PTC was 54. 1% , and the expression of BIM gene was lowered in BRAFV600E positive PTC tissues. Additionally, there was significant association( P < 0. 05) between BRAFV600E positiveness and raised TNM Staging (Ⅲ/ Ⅳ), and lowered BIM expression was significantly associated (P<0. 05) with the tumor size and raised TNM Staging(Ⅲ/ Ⅳ). These findings may help us to know more about the mechanism of PTC and to develop new diagnostic biomarkers or prognostic indicators of PTC.