MicroRNAs regulates the high density lipoprotein biogenesis and its transport
10.3760/cma.j.issn.1009-9158.2015.07.002
- VernacularTitle:MicroRNA 调控高密度脂蛋白的合成及转运
- Author:
Junjun WANG
;
Jia WU
- Publication Type:Journal Article
- Keywords:
Lipoproteins,HDL;
Biological transport;
MicroRNA
- From:
Chinese Journal of Laboratory Medicine
2015;(7):436-438
- CountryChina
- Language:Chinese
-
Abstract:
High density lipoprotein ( HDL ) has been considered as an important mediator in favoring cardioprotective effects .However , recent studies revealed that HDL-C-raising therapeutics alone failed to reduce the risk of cardiovascular diseases , suggesting that the HDLfunctionalitymay be more critical for its cardioprotective properties than the simple HDL-C levels.microRNAs ( miRNAs) have been identified as the novel regulators of lipid metabolism and played essential roles in the key steps of reverse cholesterol transport, involving in HDL biogenesis , cellular cholesterol mobilization , hepatic HDL uptake and excretion.The intensive research on lipid metabolism-related miRNAs may provide further clarification on the molecular regulatory mechanisms for HDL-mediated reverse cholesterol transport and plasma HDL-C levels, advancing our knowledge on the effects of HDL in pathogenesis and progression of cardiovascular diseases.
