Precise medical care of cardiovascular drugs under individualized medication guide
10.3760/cma.j.issn.1009-9158.2015.07.004
- VernacularTitle:心血管药物个体化用药指导的基因检测及临床意义
- Author:
Hui YUAN
- Publication Type:Journal Article
- Keywords:
Cardiovascular disease;
Genetic testing;
Polymorphism,genetic
- From:
Chinese Journal of Laboratory Medicine
2015;(7):442-444
- CountryChina
- Language:Chinese
-
Abstract:
Common drugs for cardiovascular disease include aspirin , clopidogrel, warfarin, nitroglycerin and statins etc .Because of individual differences , the effect of same drug treatment in different patients is not the same , and more and more studies found that genetic factors were important reasons to cause the efficacy of individual differences .The single nucleotide polymorphisms of important genes such as COX-1, GPⅡ b/Ⅲa, CYP2C19, CYP2C9, VKORC1, ALDH2 and that relate to drug absorption , distribution, metabolism as well as excretion have been discovered .Development of clinical gene detection and the implementation of individualized drug treatment based on genetic test results will significantly improve the therapeutic effect .The development of individualized medicine in the future on the above basis has important clinical value.
