Role of IGRA in screening of tuberculosis for children with close TB contacts

VernacularTitle:体外γ-干扰素释放试验在儿童结核病密切接触者筛查结核病的作用
Author: Yanqiong LI ; Shouyong TAN ; Zhihui LIU ; Yaoju TAN ; Yanjun HUANG ; Shaoyan KONG
Publication Type:Journal Article
Keywords: Close contact; IGRA; Tuberculosis; Children
From: The Journal of Practical Medicine 2015;31(15):2463-2466
CountryChina
Language:Chinese
Abstract: Objective To study the feasibility of in vitro release of γ-interferon tests (IGRA) in screening of tuberculosis for children with close TB contacts. Methods 185 children with close TB contacts were detected by IGRA at the pediatric clinic in our hospital. Results In IGRA-positive group, the rate of strong positive PPD (PDD≥15 mm) was 50.9%, which was higher than 9.1% in IGRA-negative group (X2 =37.263, P < 0.00). The morbidity rate for children with close TB contacts was 30.2% in IGRA-positive group, and it was significantly higher than 3.0% in IGRA-negative group (X2 = 28.928, P < 0.00). The sensitivity was 80% and the specificity was 77.6% for IGRA screening in children who had close contacts with TB patients. The sensitivity would be 95.0%, as the test was combined with PPD test. Conclusions IGRA screening in children with close TB contacts can increase the detection rate of tuberculosis and reduce imaging screening.