Short-term effect of Photofrin photodynamic adjuvant therapy for young people with advanced colorectal cancer
10.3760/cma.j.issn.1008-6315.2015.11.005
- VernacularTitle:Photofrin光动力辅助治疗青年晚期结直肠癌的近期效果观察
- Author:
Yaoming HE
- Publication Type:Journal Article
- Keywords:
Photofrin photodynamic adjuvant therapy;
Colorectal cancer;
Youth;
Adverse reaction
- From:
Clinical Medicine of China
2015;31(11):976-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the short-term efficacy and adverse drug reaction of Photofrin photodynamic adjuvant therapy for advanced colorectal cancer in young persons.Methods Selected 23 cases consecutives diagnosed as advanced colorectal cancer in young persons from September 2010 to February 2014 arriving in the Central Hospital of Jiangmen as the experiment group who were received Photofrin photodynamic therapy,and chose 30 consecutives diagnosed as advanced colorectal cancer as the control group who were received radiotherapy and chemotherapy.Using Photofrin in 2 mg/kg photosensitizer, the speed of intravenous infusion,48 hours after endoscopic into optical fiber, laser irradiation and treated with 630 nm intensity,2 days after endoscopic removal of necrotic tissue and the original lesions and new lesions were found to give according to the specific circumstances, after the removal of necrotic tissue lesions.Then compare the effects and complications.Results The total efficacy rate in experiment group was significantly more than control groupthe differences were significant (69.57％ vs.40.00％, P =0.035).The in-hospital time in experiment group was significantly less((13.47±4.46) h vs.(19.72± 5.21) h, P =0.036).The adverse drug reaction rate in experiment group was significantly lower thant the control group (30.43％ vs.50.00％ ,P=0.021).Conclusion The Photofrin photodynamic therapy for advanced colorectal cancer in young persons may greatly improve clinical effect and decrease complication.
