Expression and function of microRNAs in gallbladder cancer
10.3760/cma.j.issn.1673-9752.2015.10.021
- VernacularTitle:非编码微小RNA在胆囊癌中的表达及功能
- Author:
Chao HAN
;
Jiandong WANG
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
MicroRNAs;
Tumor genesis;
Metastasis;
Prognosis
- From:
Chinese Journal of Digestive Surgery
2015;14(10):877-880
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are a kind of small endogenous non-protein-coding single-stranded RNA,which are 18 to 25 nucleotides long.They either regulate expression of specific genes through the degradation of mRNA or repress expression of target protein of mRNA postoperation by binding with the 3' untranslated region of targeting mRNAs.It produces important physiological effects on cell proliferation, differentiation and apoptosis.The use of experimental biology and bioinformatics methods for research of tumor-associated miRNAs has become research focus.In this paper, the role of miRNAs in the oncogenesis, development, metastasis and prognosis of gallbladder cancer is mainly introduced.
