The correlation study of beta-ifbrinogen gene polymorphisms and plasma ifbrinogen concentration in patients with colorectal cancer
10.3969/j.issn.1007-3969.2015.10.009
- VernacularTitle:结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究
- Author:
Jingwen WANG
;
Tao HAN
;
Xi CHEN
;
Xi TANG
- Publication Type:Journal Article
- Keywords:
Fibrinogen;
Gene polymorphism;
Colorectal cancer
- From:China Oncology
2015;(10):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Patients with colorectal cancer are often accompanied by the increase of plasma ifbrinogen concentration. This study aimed to investigate the distribution characteristics of beta-ifbrinogen gene-448G/A, -148C/T, -1420G/A and -854G/A polymorphism and plasma ifbrinogen (Fg) concentration in patients with colorectal cancer. Furthermore, we analyzed their effects on the occurrence and development of cancer.Methods:The level of plasma Fg was quantiifed by using Clauss clotting method.FGBβ gene polymorphisms were identiifed by re-al-time lfuorescence quantitative PCR (RTFQ-PCR) in 194 colorectal cancer patients and 74 healthy controls.Results:The plasma Fg levels in tumor metastasis group and non-metastasis group were signiifcantly higher than that in control group, respectively (P<0.05). Compared with control group, the frequencies of -148T allele and mutation genotype were notably higher in disease group (P<0.05). In all the groups, the plasma Fg levels of those with -148T allele were higher than those without -148T allele (P<0.05). In stageⅣ patients, there was no difference in PFS between -148T wild gen-otype group and mutation genotype group (P>0.05).Conclusion:Plasma Fg concentration in patients with colorectal cancer was signiifcantly raised, which suggests that Fg may play a role in the occurrence and development of colorectal cancer. The beta-ifbrinogen gene -148C/T polymorphism is one of the reasons that cause plasma Fg elevation, but has no correlation with prognosis of patients with stageⅣ colorectal cancer.
