Icariin inhibits TNF-αexpression in periodental tissue during root resorption induced by rapid palatal expansion
10.3969/j.issn.1001-3733.2015.06.008
- VernacularTitle:淫羊藿苷抑制大鼠扩弓致牙根吸收过程中牙周组织 TNF-α的表达
- Author:
Zhifeng LIU
;
Feng WANG
;
Yi LIU
;
Songshan LIN
- Publication Type:Journal Article
- Keywords:
Icariin;
Root resorption;
Rapid palatal expansion;
TNF-α
- From:
Journal of Practical Stomatology
2015;(6):776-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of icariin on TNF-αexpression in periodental tissue during root resorption induced by ropid palatal expansion in rats.Methods:24 male Wistar rats were divided randomly into 3 groups(n =8)as group A(none-expansion control group),B(expansion group)and C(icariin and expansion group).In group B and C,an initial force of 50 g was applied to the area between the right and left upper first molars of the rats for 2 weeks for palatal expansion.The rats of group C were given intragastric administration of icariin at 2.5 mg/(kg·d)while the rats of group A and B were given the same dose place-bo.The centered buccal-lingual root and peridentium tissue slices were generated from the upper first molars of the rats.HE stai-ning of the slices was performed.The expression of TNF-αprotein at the compression sites was detected by irnmunohistochemistry. Results:The A values of TNF-αof group A,B and C were 0.030 2 ±0.001 7,0.241 0 ±0.002 4 and 0.088 6 ±0.002 8 respec-tively(B vs A or C,P <0.05).Conclusion:Icariin may inhibit TNF-αexpression in periodental tissue during root resorption in-duced by rapid palatal expansion.
