Clinical therapeutic effect of cattle encephalon glycoside and ignotin on ad-junctive treatment of severe hand-foot-and-mouth disease
10.3969/j.issn.1671-9638.2015.09.007
- VernacularTitle:脑苷肌肽辅助治疗重症手足口病的临床疗效观察
- Author:
Huahe LI
;
Yu WEI
- Publication Type:Journal Article
- Keywords:
hand-foot-and-mouth disease;
severe hand-foot-and-mouth disease;
cattle encephalon glycoside and ignotin;
neurological function defect;
antivirus
- From:
Chinese Journal of Infection Control
2015;(9):604-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical therapeutic effect of cattle encephalon glycoside and ignotin (EGI)on adjunc-tive therapy of severe hand-foot-and-mouth disease (HFMD).Methods 94 children with severe HFMD in a hospital were selected and divided into two groups according to the parity of patients’admission numbers,46 children in control group were given conventional therapy;48 children in trial group were given EGI adjunctive therapy based on conventional thera-py,therapeutic effect of two groups was compared.Results The total therapeutic effective rate in trial group was signifi-cantly higher than that of control group (95.83% vs 76.09%,χ2 =16.81,P <0.001 ).Neurological function score was not significantly different between two groups before therapy(P >0.05);after therapy,neurological function score in trial group was significantly lower than control group ([4.07±0.13]vs [5.59±0.18],χ2 =18.19,P <0.05).The recovery time of temperature,heart rate,blood pressure,and breathing,as well as length of stay in hospital in trial group were all significantly shorter than control group(P <0.05);incidence of complications in trial group was lower than control group (4.17%[n=2]vs 21.74%[n=10],χ2 =10.08,P <0.001 ).The proportion of turning into critically ill cases in trial group was significantly lower than control group (2.08% [n = 1 ]vs 13.04% [n = 6 ],χ2 = 8.94,P < 0.001 ). Conclusion EGI has remarkable efficacy in adjunctive therapy of severe HFMD,which can effectively improve clinical symptoms,and is worthy to be popularized and applied.
