Relationship among severity of coronary artery lesion,prognosis and thyroid dysfunction
10.3969/j.issn.1008-0074.2015.05.06
- VernacularTitle:甲状腺功能异常与冠状动脉病变严重程度及预后的关系
- Author:
Wuqi CHEN
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Hypothyroidism;
Hyperthyroidism
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(5):492-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship among severity of coronary artery lesion and prognosis and thyroid dysfunc‐tion ,.Methods:Clinical data of 577 patients undergoing coronary angiography (CAG) were retrospectively analyzed .Ac‐cording to thyroid function before CAG ,they were divided into euthyroidism group (n=507) ,hypothyroidism group (n=49) and hyperthyroidism group (n=21) .Gensini score was used to evaluate severity of coronary lesion .Patients were fol‐lowed up for one year after CAG ,and the main observing endpoints were hospitalization incidents caused by angina pectoris onset ,nonfatal myocardial infarction and heart failure .Results:Compared with euthyroidism group ,severity of coronary lesion was more severe (proportion of severe patients :22.3% vs .36.7% ) , incidence rate of coronary heart disease (59.4% vs .81.6% ) , hospitalization rate caused by angina pectoris onset (7.3% vs .14.3% ) in hypothyroidism group ;there were significant rise in incidence rate of coronary spasm (3.0% vs .33.3% ) and hospitalization rate caused by angina pectoris onset (7.5% vs .28.6% ) in hyperthyroidism group , P< 0.05 or < 0.01;in composite cardiovascular event (12.8% vs .26.5% ,38.1% ) in hypothyroidism group and hyperthyroidism group , P<0.05 all .Conclusion:Detection rate of coronary heart disease is higher ,coronary lesion is more severity and incidence rate of adverse cardiovascular event is significant rise in patients with thyroid dysfunction .
