Influence of fenofibrate on plasma BNP level and heart rate variability in aged patients with acute coro-nary syndrome
10.3969/j.issn.1008-0074.2015.05.19
- VernacularTitle:非诺贝特对老年急性冠脉综合征患者血浆脑钠肽及心率变异性的影响
- Author:
Yongsheng CHENG
;
Hualong JIANG
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Natriuretic peptide,brain;
Fenofibrate
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(5):536-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence of fenofibrate on plasma level of brain natriuretic peptide (BNP) and heart rate variability (HRV) in aged patients with acute coronary syndrome (ACS) .Methods :A total of 150 aged ACS patients undergoing treatment in our hospital were selected ,randomly and equally divided into routine treat‐ment group and fenofibrate group .Changes of plasma BNP level ,HRV parameters , blood lipid levels ,and chest pain were compared between two groups before and after treatment .Results:After treatment ,BNP level signifi‐cantly reduced ,and HRV , blood lipid levels significantly improved in both groups , P<0.01 all .Compared with routine treatment group ,plasma BNP level significantly reduced [ (132.5 ± 22.1) pg/ml vs .(91.2 ± 13.7) pg/ml] ( P<0.01);there were significant rise in standard deviation of normal to normal RR intervals calculated over the 24 h period (SDNN) ,adjacent normal RR interval difference > 50ms stroke accounted for a percentage of 24h total RR interval (PNN50) ,root‐mean square of differences between successive normal to normal intervals (rMSSD) and high frequency (HF) ,and significant reduction in low frequency (LF) ,P<0.05 all;significant reductions in levels of TC ,TG and LDL‐C ,and significant rise in HDL‐C level ( P<0.01 all);there were significant reductions in on‐set duration [ (9.53 ± 5.34) min vs .(6.32 ± 2.13) min] and frequency [ (3.87 ± 1.13) times/d vs .(2.99 ± 1.14) times/d] of chest pain after treatment in fenofibrate group , P<0.01 both .Conclusion:Routine therapy combined fenofi‐brate can significantly reduce BNP level ,regulate blood lipid and autonomic nervous function in aged ACS patients .
