Influence of statins on antiplatelet effects of clopidogrel
10.3969/j.issn.1008-0074.2015.05.21
- VernacularTitle:他汀类药物对氯吡格雷抗血小板作用的影响
- Author:
Hongsong ZHANG
;
Mingyuan LIU
;
Mei HAN
;
Feng CHEN
;
Jincheng ZHAO
;
Xue BAI
;
Yu YANG
;
Guangyuan YANG
- Publication Type:Journal Article
- Keywords:
Platelet aggregation inhibitors;
Simvastatin;
Pravastatin;
Clopidogrel
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(5):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe influence of statins on antiplatelet activity of clopidogrel and provide basis for ra‐tionality of statins combined clopidogrel treatment .Methods :According to random number table ,a total of 90 pa‐tients diagnosed as acute coronary syndrome were equally divided into clopidogrel group ,clopidogrel + simvastatin group and clopidogrel + pravastatin group . Three groups received corresponding routine medication treatment . Plasma levels of platelet αgranule membrane protein (CD62P) ,lysosomal granule membrane glycoprotein (CD63) and maximum platelet aggregation rate (MPAR) were measured and compared among three groups before and 3d af‐ter treatment .Results:Compared with before treatment ,after treatment ,there were significant reductions in plas‐ma levels of CD62P and CD63 and MPAR in three groups , P<0.01 all .After treatment ,there were no significant difference in plasma levels of CD62P [ (14.63 ± 3.45) ng/ml vs .(14.14 ± 4.32) ng/ml vs .(14.59 ± 4.23) ng/ml] , CD63 [ (26.32 ± 10.43) ng/ml vs .(27.04 ± 10.75) ng/ml vs .(27.29 ± 9.27) ng/ml] and MPAR [ (28.62 ± 17.68)% vs .(28.38 ± 16.43)% vs .(29.13 ± 14.23)% ] among clopidogrel group ,clopidogrel + simvastatin group and clopidogrel + pravastatin group ,P>0.05 all .Conclusion:Short‐term and routine dose of statins combined clo‐pidogrel is feasible in treatment of acute coronary syndrome .The combined use of them will not affect antiplatelet function of clopidogrel .
