Effect of Poria compound combined with aerobic exercise on lipid and adhesion molecules in atherosclerosis rats
10.3969/j.issn.2095-4344.2015.40.013
- VernacularTitle:茯苓复方与有氧运动干预动脉粥样硬化模型大鼠血脂及黏附分子的变化
- Author:
Qingbo GONG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(40):6465-6469
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Aerobic exercise has an anti-atherosclerosis effect and some Chinese herbal components have some interventional effects on the atherosclerosis vulnerable plaque. OBJECTIVE:To observe the effects on lipid metabolism and adhesion molecules of atherosclerotic elderly rats after the interventions of Poria compound and aerobics exercise, and explore the mechanism and prevention of hyperlipidemia-induced atherosclerosis. METHODS:Forty Spraque-Dawley elderly rats, of specific pathogen free level, were randomly divided into four groups: control group, model group, medication group, and intervention group, with 10 rats in each group. Rats in the control group were normaly fed, while rats in the other groups were intraperitonealy injected with vitamin D3 and high-fat forage for 16 weeks, to establish atherosclerosis model. During the model establishment, rats in the medication and intervention groups were given 20 g/kg Poria compound and Poria compound + 1-hour swimming, respectively. RESULTS AND CONCLUSION:Compared with the control group, total cholesterol, serum triglyceride, low-density lipoprotein expression, intercelular cel adhesion molecule-1 and lymphocyte function association antigen-1 concentrations were increased in the model group. Compared with the model group, these indexes were obviously increased in the medication and intervention groups. The serum triglyceride and low-density lipoprotein expression in the intervention group were lower than those in the medication group, while the serum high-density lipoprotein expression was higher than the medication group. Experimental findings indicate that, the combined interventions of Poria compound and aerobics exercise is better than Poria compound alone, and multi-factor treatment of atherosclerosis should be taken to enhance the efficacy of colaborative approach.
