Local injection of simvastatin for repair of mild-to-moderate unstable humeral fractures:effects on bone healing and bone density
10.3969/j.issn.2095-4344.2015.37.006
- VernacularTitle:局部注射辛伐他汀修复轻中度不稳定肱骨骨折：对骨愈合及骨密度的影响
- Author:
Jian LIU
;
Baofang TIAN
;
Wenzhu WANG
;
Weidong ZHENG
;
Li FENG
;
Baoyin DU
;
Dawei TIAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(37):5933-5937
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have shown that a single injection of smal-dose simvastatin can significantly improve bone microstructure and promote trabecular bone remodeling of the femoral condyle after osteoporosis. OBJECTIVE:To investigate the effect of local single injection of simvastatin on the prognosis of mild-to-moderate unstable humeral fractures. METHODS:A total of 93 patients with mild-to-moderate unstable humeral fracture were selected and randomized into injection group (49 cases) and normal group (44 cases). The normal group received normal physical therapy, and the injection group underwent local single injection of simvastatin based on the physical therapy. Bone mineral density and healing time were compared between two groups. RESULTS AND CONCLUSION:There was no difference in the bone mineral density between the two groups within 2 weeks after treatment (P>0.05), but the bone mineral density was significantly higher in the injection group than the normal group at 1-2 months after treatment (P<0.05). In addition, the injection group was superior to the normal group in the fol owing aspects:incidence of complications, excel ent-good rate of joint function recovery, and hospital stay. These findings indicate that the local injection of simvastatin based on conventional physical therapy can shorten the time of fracture healing, increase bone mineral density and improve the prognosis of patients with mild-to-moderate unstable proximal humeral fractures.
