Studies on immune-enhancing activity of polysaccharides from Borojoa sorbilis cuter
10.3969/j.issn.1000-484X.2015.10.010
- VernacularTitle:宝乐果多糖的体内免疫活性研究
- Author:
Ben LI
;
Kangsheng LIAO
;
Fangfang XU
;
Weiying CHEN
;
Hong JIAO
;
Bo LIU
- Publication Type:Journal Article
- Keywords:
Borojoa sorbilis cuter polysaccharides;
Immunological activities;
Cyclophosphamide-induced;
In vivo
- From:
Chinese Journal of Immunology
2015;(10):1342-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Studies on the immune-enhancing activity of Polysaccharides from the fruits of Borojoa sorbilis cuter ( polysaccharides BSCP) in vivo.Methods:54 male BALB/c mice were randomly divided into six groups.The immune suppression mice in the three experimental groups,which were induced by cyclophosphamide ( CY) at 80 mg/kg/d via intraperitoneal injection, were perfused with 100,200,400 mg/kg/d BSCP for 30 d.The effect of BSCP on cellular immune function,humoral immune function and mononuclear macrophage function were measured.Results:CY-treated mice showed a significant decrease in immune function( P<0.05),humoral immune function(P<0.01) and mononuclear macrophage function(P<0.01).The administration of BSCP was able to overcome the CY-induced immunosuppression,treatment with BSCP-L,BSCP-M and BSCP-H groups significantly enhanced the cellular immune function( each was P<0.05 ) and mononuclear macrophage function ( each was P<0.05 ) , and treatment with BSCP-M and BSCP-H significantly enhanced humoral immune function(each was P<0.01).Conclusion:BSCP could significantly increase immune responses and reduce the side effects of CY in immune system.Therefore,the BSCP could be an immunomodulatory agent.
