Research on imbalances of peripheral blood Th17 cells and Treg cells in Anaphy-lactoid purpura children
10.3969/j.issn.1000-484X.2015.10.024
- VernacularTitle:过敏性紫癜患儿外周血Th17细胞与Treg细胞失衡的研究
- Author:
Ling ZHANG
- Publication Type:Journal Article
- Keywords:
Children;
Anaphylactoid purpura;
T helper17 cells;
Regulatory T cells
- From:
Chinese Journal of Immunology
2015;(10):1404-1406
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the roles of imbalance between peripheral blood T helper17(Th17) cells and CD4+CD25+regulatory T(Treg) cells in the pathogenesis of Anaphylactoid purpura(AP).Methods: Peripheral blood samples were obtained from fifty-two patients with AP and thirty age-and sex-matched healthy controls.The percentage of Th17 cells and Treg cells in peripheral blood were detected with Flow cytometry.Furthermore,the serum level of IL-6,IL-17,IL-22 and IL-23 and transforming growth factor (TGF)-βand IL-10 were detected with the use of enzyme linked immunosorbent assay(ELISA).Results: In comparison with the controls,the AP children showed a higher percentage of Th17 cells and an increased serum level of IL-6,IL-17,IL-22 and IL-23(P<0.05),but the percentage of Treg cells and the serum level of TGF-βand IL-10 were significantly lower in AP group(P<0.05).Con-clusion:AP children experience a change in the percentage of peripheral blood T helper17 cells and CD4+CD25+regulatory T cells in peripheral blood.The imbalance between the Th17 cells and Treg cells in peripheral blood may contribute to the development of Ana-phylactoid purpura.
