Research advances on regulatory effect of RhoA on myocardial ischemia reperfusion injury
10.3969/j.issn.1001-1978.2015.10.002
- VernacularTitle:心肌缺血/再灌注中RhoA的调控作用研究进展
- Author:
Yihuang LIN
;
Lianhua FANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
RhoA;
myocardial ischemia reperfusion;
ROCK;
regulatory mechanism;
drug targets;
ischemic heart disease
- From:
Chinese Pharmacological Bulletin
2015;(10):1336-1339
- CountryChina
- Language:Chinese
-
Abstract:
RhoA belongs to the small G binding proteins Rho subfamily, playing an important role in the various cellular func-tions, including migration, proliferation, adhesion and apopto-sis. Recent data indicate that RhoA/ROCK pathway causes myo-cardial damage by influencing the myocardial energy metabolism, inflammation, and endoplasmic reticulum stress. On the other hand, the activation of RhoA also has a positive role in MIRI. This article reviews the regulatory effect of RhoA on MIRI and its mechanisms, discusses the prospects of RhoA as a novel thera-peutic target for MIRI, and provides new therapeutic treatments and strategies for MIRI.
