Synthesis of N-(4-fluorophenyl)-N-(4-phenoxyphenyl) cyclopropane-1,1-dicarboxamide
- VernacularTitle:N-（4-氟苯基）-N-（4-苯氧基苯基）环丙烷-1，1-二甲酰胺的合成研究
- Author:
Panpan SONG
;
Shouguo ZHANG
;
Tao PENG
;
Xiaoxue WEN
;
Yan MING
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
c-Met;
synthesis;
analogue;
antitumor
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize N-(4-fluorophenyl)-N-(4-phenoxyphenyl) cyclopropane-1,1-dicarboxamide (NFNPDB) as small molecular c-Met kinase inhibitor analogue.Methods N-( 4-fluorophenyl )-N-( 4-phenoxyphenyl ) cyclopropane-1, 1-dicarboxamide was synthesized by nucleophilicsubstitution, amidation, etherification, reduction and condensation from diethyl malonate.Results The total yield of target compound was 3.79%, its structure was confirmed by 1 H-NMR.Conclusion The synthesis method of NFNPDB in our research can be easily operated with lost cost and short direction, which lays the foundation for designing the synthetic process of newly small molecular c-Met kinase inhibitor.
