Microtubule-associated protein-2:regulating neuronal development, structural stability, projection formation and synaptic plasticity
10.3969/j.issn.2095-4344.2015.37.020
- VernacularTitle:微管相关蛋白2：调节神经元发育、结构稳定及突起形成和突触可塑性
- Author:
Zhongkai YAO
;
Zuopei WU
;
Guixin SUN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(37):6010-6016
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Microtubule-associated protein-2 is a kind of important regulatory factor in regulating tubulin assembly. As one of the main members of microtubule-associated proteins, microtubule-associated protein-2 plays an important role in the repairing and development of the nervous system function. It has been found that microtubule-associated protein-2 can promote the repair and rebuilding of injured nerves. OBJECTIVE:To summarize the relationship between microtubule-associated protein-2 and nerve injury as wel as the mechanism of action. METHODS:The PubMed database and CNKI database were retrieved by the fist author for the articles related to microtubule-associated protein-2 published from January 1976 to January 2015. The key words were“microtubule-associated protein-2 (MAP-2), nerve injury, progress”in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. Repetitive or old articles were excluded, and final y 82 articles were included in result analysis. RESULTS AND CONCLUSION:Microtubule-associated protein-2 is involved in nerve repair, and plays a promoting role in neuronal morphology and plasticity. To increase the concentration of microtubule-associated protein-2 contributes to the recovery of neurologic function in the early stage after nerve injury.
