MiR-18 a and estrogen receptor alpha expression in single and multiple uterine fibroids

VernacularTitle:miR-18 a和雌激素受体α在单发及多发子宫肌瘤中的表达
Author: Zhi LIAO ; Hongtao XIAO
Publication Type:Journal Article
Keywords: miR-18a; estrogen receptor alpha.multiple uterine fibroids; single uterine fibroids
From: Chinese Journal of Biochemical Pharmaceutics 2015;(9):54-56
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of miR-18a and estrogen receptor alpha (ER alpha) in single and multiple uterine flesh tumor tissues, discuss the relationship between miR-18a and ER alpha, and their effect in single and multiple uterine fibroids.Methods The expression of miR-18a and ER alpha in single and multiple uterine fibroids tissue paraffin section were detected by in situ hybridization method and immunohistochemical method, respectively.And the correlation between the miR-18a and ER alpha were evaluated.Results The expression of ER alpha in multiple uterine fibroids group was significantly higher than that of single uterine fibroids tissues (P<0.05);while miR-18a was weaker than that of single uterine fibroids tissues(P <0.05).The correlation results showed that miR-18a expression was correlated negatively with ER alpha expression either in single(r =-0.4421) and multiple uterine fibroids(r =-0.4181).Conclusion The expression of miR-18a is low in multiple uterine fibroids, while ER alpha had high expression.miR-18a could bea new target for the treatment of multiple uterine fibroids.