Efficacy of propofol compared with sevoflurane on inflammatory factor and liver function after hepatectomy
- VernacularTitle:丙泊酚与七氟烷麻醉对肝切除术患者术后炎症因子和肝脏功能的影响比较
- Author:
Lili LIU
;
Tao WANG
;
Zhixin XU
- Publication Type:Journal Article
- Keywords:
hepatectomy;
sevoflurane;
propofol;
inflammatory cytokines;
liver function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):82-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate efficacy of propofol compared with sevoflurane on inflammatory factor and liver function after hepatectomy. Methods 40 cases with hepatectomy were divided into propofol group ( P group) and sevoflurane group ( S group) , 20 cases in each group.The P group and S group respectively were given propofol or sevoflurane maintained anesthesia.The alanine aminotransferase( ALT) , total bilirubin( TBil) , aspartate amino transferase(AST), albumin(ALB), plasma tumor necrosis factor(TNF-α), interleukin-6(IL-6), interleukin-10(IL-10)and complication rate were compared between two groups.Results Postoperation 1d, 3d and 7d, the AST, ALT, and TBiL levels of S group were significantly lower than those of P group (P<0.05).There was no significant difference of ALB level between two groups.The plasma TNF-α, IL-6 and IL-10 levels of S group were significantly lower than those of P group (P<0.05).There was no significant differece of the rate of postoperative complications between S group and P group [6(30.0%) vs.10 (20.0%); χ2 =1.67, P >0.05].Conclusion Sevoflurane inhalation could effectively inhibit the plasma inflammatory cytokines secretion after hepatectomy, and promote liver function recovery, its effect is better than that of propofol.
