Effect of magnesium sulfate combined with calcium channel blockers on cystatin C,uric acid, alpha fetal protein and urinary transferrin levels in patients with hypertension pregnancy
- VernacularTitle:硫酸镁联合钙离子通道拮抗剂对妊娠期高血压患者血清胱抑素C、尿酸、甲胎蛋白及尿转铁蛋白水平的影响
- Author:
Anli CAI
;
Feiluan SONG
;
Jie QIN
;
Jie DAI
;
Qianruo PAN
;
Jieqiang LV
- Publication Type:Journal Article
- Keywords:
magnesium sulfate;
calcium channel blockers;
pregnancy induced hypertension;
Cys tatin C;
alpha fetal protein;
transferrin
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):100-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of magnesium sulfate combined with calcium channel blockers on cystatin C, uric acid, alpha fetal protein and urinary transferrin in patients with hypertension pregnancy.Methods 75 cases with hypertension of pregnancy were selected and divided into two groups, control group(n=37) were treated with conventional therapy, experiment group(n=38) were treated with magnesium sulfate combined with calcium channel blockers on the basis of control group.Cystatin C, uric acid, alpha fetal protein and urinary transferrin were compared after treatment between two groups.Results Compared with control group, Cys C, uric acid, serum AFP l, urinary TRF levels were all lower in experiment group( P<0.05), serum hematocrit, whole blood viscosity and erythrocyte aggregation index were all lower in experiment group(P<0.05).The total efficiency of experiment group was significantly higher than control group (P<0.05).Conclusion Magnesium sulfate combined with calcium channel antagonists in treatment of hypertensive disorder complicating pregnancy patients has good clinical curative effect, can effectively improve blood viscosity, reduce serum Cys C, UA, AFP and urinary TRF level.
