Effect of triple therapy and sequential therapy on eradication of Helicobacter pylori in long-term aspirin use
- VernacularTitle:三联疗法与序贯疗法在长期服用拜阿司匹林者根除幽门螺杆菌的疗效观察
- Author:
Yinhong YAN
;
Weiguo DENG
;
Xiaoliang CHEN
;
Jun CHEN
;
Jingfeng ZHOU
- Publication Type:Journal Article
- Keywords:
triple therapy;
sequential therapy;
aspirin;
eradication of Helicobacter pylori;
curative effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):106-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis curative effect of triple therapy and sequential therapy for eradication of Helicobacter pylori in patients with long-term aspirin use.Methods 52 patients with long-term aspirin use who were diagnosed with helicobacter pylori infection were collected.All patients were divided into sequential group and triple group according to different drugs classified, each 26 cases in each group were given corresponding drug treatment, after the end of treatment, the serum pepsinogen, Hp-IgG antibody levels and Helicobacter pylori clearance rate were detected in all patients. Results After treatment, compared with the triple Group, in the sequential group, the levels of serum PG I and PG II were lower, and PGⅠ/PGⅡwas higher, and the differences were statistically significant (P<0.05);the serum Hp-IgG antibody levels were lower in the sequential group (P<0.05);the Hp clearance rate of patients in the sequential group was higher (P<0.05).Conclusion Compared with triple therapy, sequential therapy can lower serum PG, PG II and Hp-IgG levels, and improve the Hp clearance rate and clinical efficacy, have guiding significance to clinical.
