Study of midazolam combined with fentanyl and propofol for painless gastrointestinal endoscopy
- VernacularTitle:咪达唑仑复合芬太尼与丙泊酚用于无痛胃肠镜检查的研究
- Author:
Hong ZHANG
;
Lina WANG
- Publication Type:Journal Article
- Keywords:
midazolam;
fentanyl;
propofol;
gastrointestinal;
endoscopy
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):112-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze feasibility and safety of sedation with midazolam combined with fentanyl and propofol in patients undergoing gastrointestinal endoscopy,and provide reference for clinical anesthesia.Methods 120 cases were selected with gastrointestinal endoscopy, then divided into observation group and control group randomly, 60 cases in each group, the observation group was anaesthetized by midazolam midazolam combined with fentanyl and propofol, the control group was anaesthetized by fentanyl combined with propofol, the change of heart rate, mean arterial pressure and oxygen saturation in different time between the observation group and the control group were compared, the induction time, the examining time, the recovery time and the time of leaving hospital, the incidence of hypotension, cardiac tachycardia, hypoxia and the incidence of adverse reactions were compared.Results The heart rate, mean arterial blood pressure and blood oxygen saturation decreased to the lowest level in 2 groups at T1.There was no significant difference in mean arterial pressure, heart rate and blood oxygen saturation between the observation group and the control group.The induction time in the observation group was shorter than the control group, and the leaving hospital time was longer than the control group(P<0.05).There was no significant difference in the incidence of hypotension and tachycardia between the two groups of patients.The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant(P<0.05).Conclusion In gastrointestinal endoscopy, midazolam combined with fentanyl and propofol is feasible and safe, because of steady hemodynamics, faster induction without prolonged recovery, reduce the incidence of adverse reactions.
