Effect of vidarabine monophosphate combined with astragalus injection on serum cTnI,IL-1β,IL-10 and TNF-αin children with hand-foot-and-mouth disease
- VernacularTitle:单磷酸阿糖腺苷联合黄芪注射液对小儿手足口病患者血清cTnI，IL-1β，IL-10及TNF-α水平的影响
- Author:
Hongfang LUO
;
Yueting LONG
;
Jianhua LIANG
;
Xihui YANG
- Publication Type:Journal Article
- Keywords:
vidarabine monophosphate;
astragalus injection;
cardiac troponin I;
interleukin 1β;
interleukin-10;
tumor necrosis factor-α
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):121-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effect of vidarabine monophosphate combined with astragalus injection on serum cardiac troponin I ( cTnI), interleukin 1β(IL-1β), interleukin-10 (IL-10) and tumor necrosis factor-α(TNF-α) in children with hand-foot-and-mouth disease.Methods 60 cases with hand-foot-and-mouth disease from March 2013 to March 2015 in the hospital were selected and divided into two groups treated by different therapy, 30 cases in each group.The control group received conventional treatment + ribavirin injection, and experimental group received vidarabine monophosphate combined with astragalus injection on the basis of conventional treatment, one time per day.All patients were treated for a course of 7 days.The serum cTnI,IL-1β,IL-10 and TNF-αlevels were compared before and after treatment.Results After treatment, the serum cTnI, IL-1β, IL-10 and TNF-αlevels in two groups decreased than those of pre-treatment (P<0.05), the above indicators of experimental group were lower than those of control group (P<0.05).Conclusion The combination of vidarabine monophosphate and astragalus injection could significantly decrease serum cTnI, IL-1β, IL-10 and TNF-αlevels in children with hand-foot-and-mouth disease.
