Study on effect of β-Sodium aescinate on vascular endothelial function, homocysteine, hypersensitive C-reactive protein and clinical efficacy in patients with acute cerebral infarction
- VernacularTitle:β-七叶皂甙钠对急性脑梗死患者血管内皮功能、同型半胱氨酸、超敏C反应蛋白及临床疗效的影响研究
- Author:
Dongmei FAN
;
Xiaoying REN
;
Ming ZHANG
;
Hengzhou LI
;
Geng WU
;
Yongsheng LIU
;
Shimei QI
- Publication Type:Journal Article
- Keywords:
β-sodium aescinate;
acute cerebral infarction;
vascular endothelial function;
homocysteine;
C-reactive protein;
clinical efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore β-sodium aescinate on vascular endothelial function ( FMD ) , homocysteine ( Hcy ) and hypersensitive C-reactive protein ( hs-CRP) and clinical efficacy in patients with acute cerebral infarction.Methods 198 acute cerebral infarction patients from March 2013 to April 2015 were randomly divided into observation group (n=100) and control group (n=98).Control group were treated according to the condition of the disease, observation group were treated by β-sodium aescinate base on control group, 20mg was added to 250mL saline for intravenous drip,one times per day.Continuous used 14d for one treatment courses.Compared the change of vascular endothelial function, Hcy and hs-CRP and clinical efficacy.Results The total effective rate of observation group was 90.00%, which was significantly higher than that of 71.42% in control group (χ2 =11.01,P<0.05).Post-treatment the value of FMD significantly increased, Hcy and hs CRP were significantly decreased both in observation group and control group respectively, which the difference had a statistically significant as compared with Pre-treatment (P<0.05);but, the value of FMD was significantly higher, Hcy and hs CRP was significantly lower in observation group than that of control group (P<0.05).Conclusion It has a significant β-sodium aescinate clinical effect in treatment of acute cerebral infarction, and FMD are significantly higher, Hcy and hs-CRP are significantly decrease.
