Study effect of dobutamine on C-reactive protein,D-dimer,BNP and blood gas analysis in children with neonatal pulmonary hypertension
- VernacularTitle:多巴酚丁胺对新生儿肺动脉高压患儿C-反应蛋白、D-二聚体、BNP水平及血气分析影响研究
- Author:
Hao CHENG
;
Ming HAO
;
Jianhua JIANG
- Publication Type:Journal Article
- Keywords:
dobutamine;
neonatal pulmonary hypertension;
C-reactive protein;
D-dimer
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):143-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse effect of dobutamine on C-reactive protein,D-dimer,BNP and blood gas analysis in children with neonatal pulmonary hypertension.Methods 46 patients who were diagnosed with neonatal pulmonary hypertension in our hospital were collected.All patients were randomly divided into experimental group and control group, 23 cases in each group.Control group was treated with sedation, maintenance of water electrolyte balance, blood pressure, anti-infection,experiment group was treated with dobutamine hydrochloride injection 5μg/(kg· min) intravenous infusion, continuous for 48 h on the basis of conventional therapy, after treatment,the levels of peripheral blood C-reactive protein, D-dimer and BNP and blood gas analysis effect were detected in all patients.Results Compared with control group post-treatment, the serum level CRP,D-dimer, BNP were lower in experimental group ( P <0.05 );the PaO2 and SpO2 levels were higher, the PAH level was lower in experimental group ( P <0.05 ) . Conclusion The dobutamine can significantly reduce the serum CRP, plasma D-dimer and BNP levels in children with neonatal pulmonary hypertension, reduce pulmonary hypertension.