Acetylation regulatory mechanism of vascular aging
10.3969/j.issn.1001-1978.2015.10.005
- VernacularTitle:血管衰老的乙酰化调控机制
- Author:
Wenjie CAI
;
Mingjie WANG
- Publication Type:Journal Article
- Keywords:
acetylation;
senescence;
endothelial cells;
hydro-gen sulfide;
angiogenesis;
histone deacetylase
- From:
Chinese Pharmacological Bulletin
2015;(10):1348-1351
- CountryChina
- Language:Chinese
-
Abstract:
Protein acetylation extensively regulates fundamental biological process, such as cardiovascular homeostasis and tu-morigenesis. Mechanism of protein acetylation and its abnormal changes during diseases has become one of the basic questions in medical research. Vascular aging is inseparable from the occur-rence and development of senile hypertension and coronary ather-osclerosis. Endothelial cell senescence plays a key role during this process. This paper reviews the research progress in acetyla-tion regulation during vascular aging, and the prospects of the re-search in this field.
