Research progress on the role of miRNAs in amphetamine-type stimulants addiction
10.3969/j.issn.1001-1978.2015.10.006
- VernacularTitle:MiRNAs在苯丙胺类兴奋剂成瘾中作用的研究进展
- Author:
Mingjin JIANG
;
Chan LI
;
Yingbo LIN
;
Daoqi ZHU
;
Zhixian MO
- Publication Type:Journal Article
- Keywords:
miRNAs;
amphetamine-type stimulants;
ampheta-mine;
methamphetamine;
addiction;
expression;
regulation;
mechanism
- From:
Chinese Pharmacological Bulletin
2015;(10):1352-1355
- CountryChina
- Language:Chinese
-
Abstract:
Amphetamine-type stimulants ( ATS ) , a group of new-type synthetic drugs mainly in psychological dependence, are abused more and more severely in recent years. MicroRNAs ( MiRNAs ) are an important class of endogenous non-coding small RNAs that mediate posttranscriptional negatively regulation of gene expression by targeting specific mRNA sequences to in-hibit the translation of mRNAs or degrade the expression of mR-NAs. ATS can induce the changes in the expression of miRNAs in addiction-related brain regions which directly involve in the regulation of ATS-induced addictive behaviors. Therefore, to study the regulatory role of miRNAs in ATS-induced addiction has important implications for dependent mechanisms of new-type drugs and the discovery of the new targets of drug actions.
