Protective effects of salidroside in MCAO rats
10.3969/j.issn.1001-1978.2015.10.025
- VernacularTitle:红景天苷对大脑中动脉闭塞模型大鼠的神经保护作用
- Author:
Xiuli XIE
;
Haimian HONG
;
Wenfang LAI
;
Xiaoqin ZHANG
;
Guizhu HONG
- Publication Type:Journal Article
- Keywords:
salidroside;
cerebral ischemia-reperfusion injury;
Cluster analysis;
gene chip;
inflammation;
cell apoptosis;
neuroprotection
- From:
Chinese Pharmacological Bulletin
2015;(10):1452-1457
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the neuroprotective effect of salidroside in MCAO rats. Methods The rats were subjected to middle cerebral artery occlusion with suture-occluded method, and the neurologic injury and infarct size of rats were evaluated. According to the gene chip detected, the protein expressions of caspase-3 , cleaved caspase-3 were determined and the mRNA expressions of IL-6, Vgf, Hba-a2, Hbb-b1, Hbb, CD44, Pnpla2, Slc6a5 and Slc5a7 were tested. Re-sults Compared with MCAO group, salidroside signif-icantly improved the neurological deficit, reduced the infarct sizes, inhibited the expressions of cleaved caspase-3 protein and IL-6 mRNA, promoted the ex-pressions of Vgf, Hba-a2, Hbb-b1, Hbb, and reduced the expressions of CD44 , Pnpla2 , Slc6 a5 and Slc5 a7 . Conclusions Salidroside can reduce the neurological deficit and infarct size, and protect rats against focal cerebral ischemia-reperfusion injury, which may be ac-complished by increasing the expressions of Vgf, Hba-a2, Hbb-b1, and Hbb, and decreasing the expressions of cleaved caspase-3 , IL-6 , CD44 , Pnpla2 , Slc6 a5 and Slc5 a7 .
