Effect of stem cell transplantation on serum homocysteine, CRP and BDNF in patients with ischemic stroke
- VernacularTitle:干细胞移植对缺血性脑卒中患者血清同型半胱氨酸、CRP及BDNF含量影响研究
- Author:
Moushan CAI
;
Chunlin SHEN
;
Linghai ZENG
;
Xiaoqun HUANG
;
Chengwei SONG
- Publication Type:Journal Article
- Keywords:
stem cell transplantation;
ischemic stroke;
homocysteine;
C reaction protein;
brain derived neurotrophic factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of stem cell transplantation on serum homocysteine ( Hcy ) , C reactive protein ( CRP ) and brain derived neurotrophic factor( BDNF) in patients with ischemic stroke.Methods 42 patients who were diagnosed with ischemic stroke in Yichang First People's Hospital were collected.All patients were randomly divided into experimental group and control group, 21 cases in each group.The control group was treated with conventional therapy, and the experimental group was treated with autologous bone marrow mesenchymal stem cell transplantation for treatment on the basis of conventional therapy, after treatment, the serum levels of serum homocysteine, CRP, BDNF and clinical curative effect were detected in all patients.Results After treatment, compared with control group, the serum Hcy level was lower in the experimental group(P<0.05);the serum CRP level was lower in the experimental group (P<0.05); the serum BDNF level was higher in the experimental group (P<0.05); the FIM, ADL and Fugl-Meyer score were higher in the experimental group(P <0.05).Conclusions The stem cell transplantation can significantly reduce the serum Hcy and CRP levels in patients with ischemic stroke, increase the content of BDNF in serum, improve the therapeutic effect, and have a guiding significance for clinical.
