Effect of Teprenone Combined with Rabeprazole on Prevention of Bleeding after Gastric ESD
10.3969/j.issn.1008-7125.2015.09.008
- VernacularTitle:替普瑞酮联合雷贝拉唑预防胃 ESD术后出血的疗效研究
- Author:
Haiyan LI
;
Xiaobo LI
- Publication Type:Journal Article
- Keywords:
Endoscopic Submucosal Dissection;
Stomach Ulcer;
Postoperative Hemorrhage;
Teprenone;
Rabeprazole;
Therapy
- From:Chinese Journal of Gastroenterology
2015;(9):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Background:As a minimally invasive treatment of early gastric cancer,endoscopic submucosal dissection(ESD) proves it could reduce postoperative complications and improve the quality of patients’life. However,ESD-induced gastric ulcer remains a problem. Aims:To evaluate the effect of teprenone combined with rabeprazole on post-ESD ulcer healing and prevention of bleeding after gastric ESD. Methods:One hundred and twenty cases of early gastric cancer or precancerous lesion treated by gastric ESD were divided randomly into group A and group B. Patients in group A were given teprenone combined with rabeprazole,while patients in group B were given rabeprazole alone. The treatment course was 8 weeks. Delayed bleeding rate after ESD and ulcer healing in the two groups were compared. Results:No significant difference was found in rate of delayed bleeding after ESD between the two groups(P = 0. 679). The stage of ulcer had no differences after 7 days of ESD(P > 0. 05),while showed a better healing stage in group A after 30 days and 60 days of ESD(P < 0. 05). The rates of decreased size and area of ulcer were higher in group A after 30 days of ESD(P < 0. 05), while had no statistical differences after 60 days of ESD(P > 0. 05). Conclusions:Teprenone can effectively promote post ESD ulcer healing,especially in the early stage of healing,thus reducing the rate of bleeding after gastric ESD.
